Temporal Dynamics of the Intestinal Microbiome Following Short-Term Dietary Restriction.

ABSTRACT: Short-term dietary restriction has been proposed as an intriguing pre-operative conditioning strategy designed to attenuate the surgical stress response and improve outcomes. However, it is unclear how this nutritional intervention influences the microbiome, which is known to modulate the systemic condition. Healthy individuals were recruited to participate in a four-day, 70% protein-restricted, 30% calorie-restricted diet, and stool samples were collected at baseline, after the restricted diet, and after resuming normal food intake. Taxonomy and functional pathway analysis was performed via shotgun metagenomic sequencing, prevalence filtering, and differential abundance analysis. High prevalence species were altered by the dietary intervention but quickly returned to baseline after restar

SUBMITTER: Anderson EM 

PROVIDER: S-EPMC9318361 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature