Stem Cell Therapy in Neuroimmunological Diseases and Its Potential Neuroimmunological Complications.

ABSTRACT: Background: Since the 1990s, transplantations of hematopoietic and mesenchymal stem cells (HSCT and MSCT) and dendritic cell (DCT) have been investigated for the treatment of neurological autoimmune disorders (NADs). With the growing number of transplanted patients, awareness of neuroimmunolgical complications has increased. Therefore, an overview of SCT for the most common NADs and reports of secondary immunity after SCT is provided. Methods: For this narrative review, a literature search of the PubMed database was performed. A total of 86 articles reporting on different SCTs in NADs and 61 articles dealing with immune-mediated neurological complications after SCT were included. For multiple sclerosis (MS), only registered trials and phase I/II or II studies were considered,

SUBMITTER: Konen FF 

PROVIDER: S-EPMC9318423 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature