The Type III Secretion Effector CteG Mediates Host Cell Lytic Exit of Chlamydia trachomatis.

ABSTRACT: Chlamydia trachomatis is an obligate intracellular bacterium causing ocular and urogenital infections in humans that are a significant burden worldwide. The completion of its characteristic infectious cycle relies on the manipulation of several host cell processes by numerous chlamydial type III secretion effector proteins. We previously identified the C. trachomatis CteG effector and showed it localizes at the host cell plasma membrane at late stages of infection. Here, we showed that, from 48 h post-infection, mammalian cells infected by wild-type C. trachomatis contained more infectious chlamydiae in the culture supernatant than cells infected by a CteG-deficient strain. This phenotype was CteG-dependent as it could be complemented in cells infected by the CteG-defi

SUBMITTER: Pereira IS 

PROVIDER: S-EPMC9318579 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature