New Genetic Technologies in Diagnosis and Treatment of Cancer of Unknown Primary.

ABSTRACT: Cancer of unknown primary (CUP) represents a rare oncological and heterogeneous disease in which one or more metastases are present, but the location of the primary site is unknown. Pathological diagnosis, using immunohistochemistry, of such metastatic materials is challenging and frequently does not allow for determining the tissue of origin (ToO). The selection of systemic therapy in patients with CUP is usually based on empiric grounds, and the prognosis is generally unfavourable. New molecular techniques could identify the tissue of origin and be used to select systemic agnostic therapies in various malignancies with specific molecular abnormalities. Targetable driver mutations or gene rearrangements in cancer cells may be identified using various molecular assays, of which particularl

SUBMITTER: Krawczyk P 

PROVIDER: S-EPMC9318615 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature