Low Doses of PFOA Promote Prostate and Breast Cancer Cells Growth through Different Pathways.

ABSTRACT: Endocrine Disrupting Compounds (EDCs) are found in everyday products. Widely distributed throughout the environment, persistent organic pollutants (POPs) are a specific class of EDCs that can accumulate in adipose tissue. Many of them induce adverse effects on human health-such as obesity, fertility disorders and cancers-by perturbing hormone effects. We previously identified many compounds with EDC activity in the circulation of obese patients who underwent bariatric surgery. Herein, we analyzed the effects of four of them (aldrin, BDE28, PFOA and PCB153) on two cancer cell lines of hormone-sensitive organs (prostate and breast). Each cell line was exposed to serial dilutions of EDCs from 10^-6 M to 10^-12 M; cytotoxicity and proliferation were monitored using the Incu

SUBMITTER: Charazac A 

PROVIDER: S-EPMC9318902 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature