Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice.

ABSTRACT: Acute brain inflammation after status epilepticus (SE) is involved in blood-brain barrier (BBB) dysfunction and brain edema, which cause the development of post-SE symptomatic epilepsy. Using pilocarpine-induced SE mice, we previously reported that treatment with levetiracetam (LEV) after SE suppresses increased expression levels of proinflammatory mediators during epileptogenesis and prevents the development of spontaneous recurrent seizures. However, it remains unclear how LEV suppresses neuroinflammation after SE. In this study, we demonstrated that LEV suppressed the infiltration of CD11b⁺CD45^high cells into the brain after SE. CD11b⁺CD45^high cells appeared in the hippocampus between 1 and 4 days after SE and contained Ly6G⁺Ly6C

SUBMITTER: Matsuo T 

PROVIDER: S-EPMC9319101 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature