«Salivaomics» of Different Molecular Biological Subtypes of Breast Cancer.

ABSTRACT: The aim of the study was to determine the metabolic characteristics of saliva depending on the molecular biological subtype of breast cancer, as well as depending on the expression levels of HER2, estrogen receptors (ER), and progesterone receptors (PR). The study included 487 patients with morphologically verified breast cancer and 298 volunteers without breast pathologies. Saliva samples were obtained from all patients strictly before the start of treatment and the values of 42 biochemical indicators were determined. It has been established that the saliva of healthy volunteers and patients with various molecular biological subtypes of breast cancer differs in 12 biochemical indicators: concentrations of protein, urea, nitric oxide, malondialdehyde, total amino acid content, and activity

SUBMITTER: Bel'skaya LV 

PROVIDER: S-EPMC9319144 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature