The Short-Term Opening of Cyclosporin A-Independent Palmitate/Sr²⁺-Induced Pore Can Underlie Ion Efflux in the Oscillatory Mode of Functioning of Rat Liver Mitochondria.

ABSTRACT: Mitochondria are capable of synchronized oscillations in many variables, but the underlying mechanisms are still unclear. In this study, we demonstrated that rat liver mitochondria, when exposed to a pulse of Sr²⁺ ions in the presence of valinomycin (a potassium ionophore) and cyclosporin A (a specific inhibitor of the permeability transition pore complex) under hypotonia, showed prolonged oscillations in K⁺ and Sr²⁺ fluxes, membrane potential, pH, matrix volume, rates of oxygen consumption and H₂O₂ formation. The dynamic changes in the rate of H₂O₂ production were in a reciprocal relationship with the respiration rate and in a direct relationship with the mitochondrial membrane potential and other indicators stud

SUBMITTER: Belosludtseva NV 

PROVIDER: S-EPMC9319229 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature