Transcriptomic Analysis Reveals the Role of tmRNA on Biofilm Formation in Bacillus subtilis.

ABSTRACT: Bacillus strains are widely distributed in terrestrial and marine environments, and some of them are used as biocontrol organisms for their biofilm-formation ability. In Bacillus subtilis, biofilm formation is fine-tuned by a complex network, a clear understanding of which still requires study. In bacteria, tmRNA, encoded by the ssrA gene, catalyzes trans-translation that can rescue ribosomes stalled on mRNA transcripts lacking a functional stop codon. tmRNA also affects physiological bioprocesses in some bacteria. In this study, we constructed a ssrA mutant in B. subtilis and found that the biofilm formation in the ssrA mutant was largely impaired. Moreover, we isolated a biofilm-formation suppressor of ssrA, in which the biofilm for

SUBMITTER: Xu S 

PROVIDER: S-EPMC9319509 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature