Urinary Sodium Excretion Enhances the Effect of Alcohol on Blood Pressure.

ABSTRACT: Alcohol consumption is linked to urinary sodium excretion and both of these traits are linked to hypertension and cardiovascular diseases (CVDs). The interplay between alcohol consumption and sodium on hypertension, and cardiovascular diseases (CVDs) is not well-described. Here, we used genetically predicted alcohol consumption and explored the relationships between alcohol consumption, urinary sodium, hypertension, and CVDs.

Methods

We performed a comparative analysis among 295,189 participants from the prospective cohort of the UK Biobank (baseline data collected between 2006 and 2010). We created a genetic risk score (GRS) using 105 published genetic variants in Europeans that were associated with alcohol consumption. We explored the relationships between GRS, alcohol consumption

SUBMITTER: Jiang X 

PROVIDER: S-EPMC9319523 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature