Role of Transposable Elements in Genome Stability: Implications for Health and Disease.

ABSTRACT: Most living organisms have in their genome a sizable proportion of DNA sequences capable of mobilization; these sequences are commonly referred to as transposons, transposable elements (TEs), or jumping genes. Although long thought to have no biological significance, advances in DNA sequencing and analytical technologies have enabled precise characterization of TEs and confirmed their ubiquitous presence across all forms of life. These findings have ignited intense debates over their biological significance. The available evidence now supports the notion that TEs exert major influence over many biological aspects of organismal life. Transposable elements contribute significantly to the evolution of the genome by giving rise to genetic variations in both active and passive modes. Due to the

SUBMITTER: Bhat A 

PROVIDER: S-EPMC9319628 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature