Oleuropein as a Potent Compound against Neurological Complications Linked with COVID-19: A Computational Biology Approach.

ABSTRACT: The association of COVID-19 with neurological complications is a well-known fact, and researchers are endeavoring to investigate the mechanistic perspectives behind it. SARS-CoV-2 can bind to Toll-like receptor 4 (TLR-4) that would eventually lead to α-synuclein aggregation in neurons and stimulation of neurodegeneration pathways. Olive leaves have been reported as a promising phytotherapy or co-therapy against COVID-19, and oleuropein is one of the major active components of olive leaves. In the current study, oleuropein was investigated against SARS-CoV-2 target (main protease 3CL^pro), TLR-4 and Prolyl Oligopeptidases (POP), to explore oleuropein potency against the neurological complications associated with COVID-19. Docking experiments, docking validation, interaction analys

SUBMITTER: Hussain T 

PROVIDER: S-EPMC9319675 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature