Impact of CFTR Modulators on Beta-Cell Function in Children and Young Adults with Cystic Fibrosis.

ABSTRACT:

Background

To date, no consistent data are available on the possible impact of CFTR modulators on glucose metabolism. The aim of this study was to test the hypothesis that treatment with CFTR modulators is associated with an improvement in the key direct determinants of glucose regulation in children and young adults affected by Cystic Fibrosis (CF).

Methods

In this study, 21 CF patients aged 10-25 underwent oral glucose tolerance test (OGTT) before and after 12-18 months of treatment with Lumacaftor/Ivacaftor or Elexacaftor-Ivacaftor-Tezacaftor. β-cell function (i.e., first and second phase of insulin secretion measured as derivative and proportional control, respectively) and insulin clearance were estimated by OGTT mathematical modelling. Insulin sensitivity was estimated

SUBMITTER: Piona C 

PROVIDER: S-EPMC9319690 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature