Vascular Calcification Is Associated with Fetuin-A and Cortical Bone Porosity in Stone Formers.

ABSTRACT:

Background

Nephrolithiasis has been associated with bone loss and vascular calcification (VC), reflecting abnormal extraosseous calcium deposition. Fetuin-A (Fet-A) acts as a potent inhibitor of ectopic mineralization. The aim of the present study was to evaluate the prevalence of VC in stone formers (SF) and non-stone formers (NSF) and to investigate potential determinants of VC among SF, including circulating levels of Fet-A and bone microarchitecture parameters.

Methods

Abdominal aortic calcification (AAC) was assessed using available computed tomography in SF and in age-, sex-, and BMI-matched NSF (potential living kidney donors). Serum Fet-A was measured in stored blood samples from SF. Bone microarchitecture parameters were obtained as a post hoc analysis of a cross-se

SUBMITTER: Rodrigues FG 

PROVIDER: S-EPMC9319706 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature