Risk Assessment for Birth Defects in Offspring of Chinese Pregnant Women.

ABSTRACT:

Objective

This study aimed to develop a nomogram for the risk assessment of any type of birth defect in offspring using a large birth-defect database in Northwest China.

Methods

This study was based on a birth-defect survey, which included 29,204 eligible women who were pregnant between 2010 and 2013 in the Shaanxi province of Northwest China. The participants from central Shaanxi province were assigned to the training group, while the subjects from the south and north of Shaanxi province were assigned to the external validation group. The primary outcome was the occurrence of any type of birth defect in the offspring. A multivariate logistic regression model was used to establish a prediction nomogram, while the discrimination and calibration were evaluated by external vali

SUBMITTER: Qu P 

PROVIDER: S-EPMC9319985 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature