Rational Discovery of Antimicrobial Peptides by Means of Artificial Intelligence.

ABSTRACT: Antibiotic resistance is a worldwide public health problem due to the costs and mortality rates it generates. However, the large pharmaceutical industries have stopped searching for new antibiotics because of their low profitability, given the rapid replacement rates imposed by the increasingly observed resistance acquired by microorganisms. Alternatively, antimicrobial peptides (AMPs) have emerged as potent molecules with a much lower rate of resistance generation. The discovery of these peptides is carried out through extensive in vitro screenings of either rational or non-rational libraries. These processes are tedious and expensive and generate only a few AMP candidates, most of which fail to show the required activity and physicochemical properties for practical applications. This wor

SUBMITTER: Ruiz Puentes P 

PROVIDER: S-EPMC9320227 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature