Natural and Induced Tolerance to Hymenoptera Venom: A Single Mechanism?

ABSTRACT: Inducing tolerance in Hymenoptera-allergic patients, bee venom immunotherapy (BVIT) is a widely accepted method to treat severe allergy to bee stings. In order to increase the existing knowledge on the underlying immunological mechanisms and look for possible biomarkers predictive of efficacy, a group of 20 bee-venom-allergic patients (AG) were thoroughly examined during their first year of BVIT. In addition, the results of treated patients with those of an untreated group of 20 tolerant beekeepers (TG) who had previously shown a firm suppressor-regulatory profile were compared. Tolerance in AG patients was invariably associated with a significant regulatory response characterised by the expansion of Helios^- subpopulation and increased IL-10, specific IgG4 (sIgG4), and kynurenin

SUBMITTER: Navas A 

PROVIDER: S-EPMC9320229 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature