Functional Genomics Analysis to Disentangle the Role of Genetic Variants in Major Depression.

ABSTRACT: Understanding the molecular basis of major depression is critical for identifying new potential biomarkers and drug targets to alleviate its burden on society. Leveraging available GWAS data and functional genomic tools to assess regulatory variation could help explain the role of major depression-associated genetic variants in disease pathogenesis. We have conducted a fine-mapping analysis of genetic variants associated with major depression and applied a pipeline focused on gene expression regulation by using two complementary approaches: cis-eQTL colocalization analysis and alteration of transcription factor binding sites. The fine-mapping process uncovered putative causally associated variants whose proximal genes were linked with major depression pathophysiology. Four colocalizing gen

SUBMITTER: Perez-Granado J 

PROVIDER: S-EPMC9320424 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature