Fiscalin Derivatives as Potential Neuroprotective Agents.

ABSTRACT: Neurodegenerative diseases (ND) share common molecular/cellular mechanisms that contribute to their progression and pathogenesis. In this sense, we are here proposing new neuroprotection strategies by using marine-derived compounds as fiscalins. This work aims to evaluate the protective effects of fiscalin derivatives towards 1-methyl-4-phenylpyridinium (MPP⁺)- and iron (III)-induced cytotoxicity in differentiated SH-SY5Y cells, an in vitro disease model to study ND; and on P-glycoprotein (P-gp) transport activity, an efflux pump of drugs and neurotoxins. SH-SY5Y cells were simultaneously exposed to MPP⁺ or iron (III), and noncytotoxic concentrations of 18 fiscalin derivatives (0-25 μM), being the cytotoxic effect of both MPP⁺ and iron (III) evaluated 24 an

SUBMITTER: Barreiro S 

PROVIDER: S-EPMC9320635 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature