The first reptilian allergen and major allergen for fish-allergic patients: Crocodile β-parvalbumin.

ABSTRACT:

Background

Clinical cross-reactivity between bony fish, cartilaginous fish, frog, and chicken muscle has previously been demonstrated in fish-allergic patients. In indicative studies, two reports of anaphylaxis following the consumption of crocodile meat and IgE-cross-binding were linked to the major fish allergen parvalbumin (PV). This study investigates IgE-binding proteins in crocodile meat with a focus on PV and their clinical relevance.

Methods

Proteins were extracted from muscle tissue of crocodile, three bony fish, and two cartilaginous fish. A cohort of fish-allergic pediatric patients (n = 77) underwent allergen skin prick testing (SPT) to three fish preparations (n = 77) and crocodile (n = 12). IgE-binding proteins were identified and quantified by SDS-PAGE, mass s

SUBMITTER: Ruethers T 

PROVIDER: S-EPMC9320800 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature