Incidence and determinants of thrombotic and bleeding complications in patients with glioblastoma.

ABSTRACT:

Background

Glioblastoma patients are considered to be at high risk of venous thromboembolism (VTE) and major bleeding (MB), although reliable incidence estimates are lacking. Moreover, the risk of arterial thromboembolism (ATE) in these patients is largely unknown. Our aim was to assess the cumulative incidence, predictors, and prognostic impact of VTE, ATE, and MB on subsequent complications and mortality.

Methods

Cohort study of 967 consecutive patients diagnosed with glioblastoma between 2004-2020 in two hospitals. Patients were followed from 6 months before date of histopathological glioblastoma diagnosis up to 2 years after, or until an outcome of interest (VTE, ATE, and MB) or death occurred, depending on the analysis. Cumulative incidences were estimated with death as

SUBMITTER: Kaptein FHJ 

PROVIDER: S-EPMC9320838 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature