Luminescent Pyrrole-Based Phosphaphenalene Gold Complexes: Versatile Anticancer Tools with Wide Applicability.

ABSTRACT: Brain cancer, one of the most lethal diseases, urgently requires the discovery of novel theranostic agents. In this context, molecules based on six-membered phosphorus heterocycles - phosphaphenalenes - are especially attractive; they possess unique characteristics that allow precise chemical engineering. Herein, we demonstrate that subtle structural modifications of the phosphaphenalene-based gold(I) complexes lead to modify their electronic distribution, endow them with marked photophysical properties and enhance their efficacy against cancer. In particular, phosphaphenalene-based gold(I) complexes containing a pyrrole ring show antiproliferative properties in 14 cell lines including glioblastomas, brain metastases, meningiomas, IDH-mutant gliomas and head and neck cancers, reaching IC

SUBMITTER: Fermi V 

PROVIDER: S-EPMC9320851 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature