Internal Relative Potency Factors for the Risk Assessment of Mixtures of Per- and Polyfluoroalkyl Substances (PFAS) in Human Biomonitoring.

ABSTRACT:

Background

In human biomonitoring, blood is often used as a matrix to measure exposure to per- and polyfluoroalkyl substances (PFAS). Because the toxicokinetics of a substance (determining the steady-state blood concentration) may affect the toxic potency, the difference in toxicokinetics among PFAS has to be accounted for when blood concentrations are used in mixture risk assessment.

Objectives

This research focuses on deriving relative potency factors (RPFs) at the blood serum level. These RPFs can be applied to PFAS concentrations in human blood, thereby facilitating mixture risk assessment with primary input from human biomonitoring studies.

Methods

Toxicokinetic models are generated for 10 PFAS to estimate the internal exposure in the male rat at the blood serum

SUBMITTER: Bil W 

PROVIDER: S-EPMC9320915 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature