New Anti-Flavivirus Fusion Loop Human Antibodies with Zika Virus-Neutralizing Potential.

ABSTRACT: Zika virus infections exhibit recurrent outbreaks and can be responsible for disease complications such as congenital Zika virus syndrome. Effective therapeutic interventions are still a challenge. Antibodies can provide significant protection, although the antibody response may fail due to antibody-dependent enhancement reactions. The choice of the target antigen is a crucial part of the process to generate effective neutralizing antibodies. Human anti-Zika virus antibodies were selected by phage display technology. The antibodies were selected against a mimetic peptide based on the fusion loop region in the protein E of Zika virus, which is highly conserved among different flaviviruses. Four rounds of selection were performed using the synthetic peptide in two strategies: the first was u

SUBMITTER: Franca RKAO 

PROVIDER: S-EPMC9321016 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature