Nickel-Catalyzed C_sp2 -OMe Functionalization for Chemoselective Aromatic Homologation En Route to Nanographenes.

ABSTRACT: A Ni-catalyzed C_sp2 -OMe ortho-functionalization methodology to form chemoselectively alkyne monoannulation or aromatic homologation products is reported as a novel protocol towards the valorisation of substrates containing C_sp2 -OMe units. Double activation of C_sp2 -OMe and C_sp2 -F bonds is also demonstrated. Further use of aromatic homologation products towards the synthesis of nanographene-like compounds is described.

SUBMITTER: Capdevila L 

PROVIDER: S-EPMC9321019 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature