Implications of the Actin Cytoskeleton on the Multi-Step Process of [PSI⁺] Prion Formation.

ABSTRACT: Yeast prions are self-perpetuating misfolded proteins that are infectious. In yeast, [PSI⁺] is the prion form of the Sup35 protein. While the study of [PSI⁺] has revealed important cellular mechanisms that contribute to prion propagation, the underlying cellular factors that influence prion formation are not well understood. Prion formation has been described as a multi-step process involving both the initial nucleation and growth of aggregates, followed by the subsequent transmission of prion particles to daughter cells. Prior evidence suggests that actin plays a role in this multi-step process, but actin's precise role is unclear. Here, we investigate how actin influences the cell's ability to manage newly formed visible aggregates and how actin influe

SUBMITTER: Dorweiler JE 

PROVIDER: S-EPMC9321047 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature