Longitudinal changes in lung function in very prematurely born young people receiving high-frequency oscillation or conventional ventilation from birth.

ABSTRACT:

Objective

To examine changes in lung function over time in extremely prematurely born adolescents.

Working hypothesis

Changes in lung function during adolescence would vary by ventilation mode immediately after birth.

Study design

Longitudinal follow-up study.

Patient subject selection

Participants from the United Kingdom Oscillation Study who were randomized at birth to high-frequency oscillation (HFO) or conventional ventilation (CV) were assessed at 11-14 years (n = 319) and at 16-19 years (n = 159).

Methodology

Forced expiratory flow (FEF), forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and lung volumes including functional residual capacity (FRC) were reported as z-scores. The diffusion capacity of the lungs for carbon monoxide

SUBMITTER: Bisquera A 

PROVIDER: S-EPMC9321071 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature