DRD4 polymorphism associated with greater positive affect in response to negative and neutral social stimuli.

ABSTRACT: Despite the robustness of DRD4 polymorphism associations with brain-based behavioral characteristics in candidate gene research, investigations have minimally explored associations between these polymorphisms and emotional responses. In particular, the prevalent single nucleotide polymorphism (SNP) -521C/T (rs1800955) in the promoter region of DRD4 remains unexplored relative to emotions. Here, two independent samples were evaluated using different emotion elicitation tasks involving social stimuli: Study 1 (N = 120) evoked positive and negative emotional responses to validated film clips; Study 2 (N = 122) utilized Cyberball to simulate social rejection and acceptance. Across studies, C/C individuals self-reported higher mean positive affect scores using Likert scales versus T carrier ind

SUBMITTER: Gilman TL 

PROVIDER: S-EPMC9321090 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature