Exploring compounds to be used as cosmetic agents that activate peroxisome proliferator-activated receptor alpha.

ABSTRACT:

Objective

The human epidermis is formed by the proliferation and differentiation of keratinocytes adjacent to the basement membrane. The outermost layer, the stratum corneum, is equipped with a barrier function that prevents water evaporation, and intercellular lipids play an important role in this barrier function. When the barrier is functioning normally, evaporation is prevented; however, when barrier function is impaired, moisture evaporates, resulting in dry and rough skin. Therefore, maintenance of normal barrier function is critical for maintaining normal skin function. Peroxisome proliferator-activated receptor α (PPARα) is mainly not only involved in lipid metabolism in the liver but is also expressed in the epidermis and is involved in inducing keratinocyte differentiatio

SUBMITTER: Tachibana K 

PROVIDER: S-EPMC9321093 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature