Technical note: Impact of beamline-specific particle energy spectra on clinical plans in carbon ion beam therapy.

ABSTRACT:

Purpose

The Local Effect Model version one (LEM I) is applied clinically across Europe to quantify the relative biological effectiveness (RBE) of carbon ion beams. It requires the full particle fluence spectrum differential in energy in each voxel as input parameter. Treatment planning systems (TPSs) use beamline-specific look-up tables generated with Monte Carlo (MC) codes. In this study, the changes in RBE weighted dose were quantified using different levels of details in the simulation or different MC codes.

Methods

The particle fluence differential in energy was simulated with FLUKA and Geant4 at 500 depths in water in 1-mm steps for 58 initial carbon ion energies (between 120.0 and 402.8 MeV/u). A dedicated beam model was applied, including the full description of the N

SUBMITTER: Resch AF 

PROVIDER: S-EPMC9321194 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature