New Glycosylated Secondary Metabolites from Marine-Derived Bacteria.

ABSTRACT: Three new glycosylated secondary metabolites, including a new indole alkaloid, pityriacitrin D (1), and two new trehalose lipids (2 and 3), together with three known compounds (4-6) were isolated from two marine-derived bacterial strains, Bacillus siamensis 168CLC-66.1 and Tsukamurella pseudospumae IV19-045. The structures of 1-3 were determined by extensive analysis and comparison of their spectroscopic data with literature values. The absolute configurations of sugar moieties were determined by chemical derivatization followed by LC-MS analysis. Cytotoxicity of 1-3 against six cancer cell lines was evaluated by SRB assay, and 1 showed moderate activity against all the tested cell lines with GI₅₀ values ranging from 8.0 to 10.9 µM.

SUBMITTER: Anh CV 

PROVIDER: S-EPMC9321207 | biostudies-literature |

REPOSITORIES: biostudies-literature