Etramp5 as a useful serological marker in children to assess the immediate effects of mass drug campaigns for malaria.

ABSTRACT:

Introduction

Serological methods provide useful metrics to estimate age-specific period prevalence in settings of low malaria transmission; however, evidence on the use of seropositivity as an endpoint remains scarce in studies to evaluate combinations of malaria control measures, especially in children. This study aims to evaluate the immediate effects of a targeted mass drug administration campaign (tMDA) in Haiti by using serological markers.

Methods

The tMDA was implemented in September-October 2018 using sulfadoxine-pyrimethamine and single low-dose primaquine. A natural quasi-experimental study was designed, using a pretest and posttest in a cohort of 754 randomly selected school children, among which 23% reported having received tMDA. Five antigens were selected as ou

SUBMITTER: Druetz T 

PROVIDER: S-EPMC9321307 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature