Characterization in Inhibitory Effectiveness of Carbamazepine in Voltage-Gated Na⁺ and Erg-Mediated K⁺ Currents in a Mouse Neural Crest-Derived (Neuro-2a) Cell Line.

ABSTRACT: Carbamazepine (CBZ, Tegretol^®) is an anticonvulsant used in the treatment of epilepsy and neuropathic pain; however, several unwanted effects of this drug have been noticed. Therefore, the regulatory actions of CBZ on ionic currents in electrically excitable cells need to be reappraised, although its efficacy in suppressing voltage-gated Na⁺ current (I_Na) has been disclosed. This study was undertaken to explore the modifications produced by CBZ on ionic currents (e.g., I_Na and erg-mediated K⁺ current [I_K(erg)]) measured from Neuro-2a (N2a) cells. In these cells, we found that this drug differentially suppressed the peak (transient, I_Na(T)) and sustained (late, I_Na(L)<

SUBMITTER: Wu PM 

PROVIDER: S-EPMC9321339 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature