Descriptive transcriptome analysis of tendon derived fibroblasts following in-vitro exposure to advanced glycation end products.

ABSTRACT:

Background

Tendon pathologies affect a large portion of people with diabetes. This high rate of tendon pain, injury, and disease appears to manifest independent of well-controlled HbA1c and fasting blood glucose. Advanced glycation end products (AGEs) are elevated in the serum of those with diabetes. In vitro, AGEs severely impact tendon fibroblast proliferation and mitochondrial function. However, the extent that AGEs impact the tendon cell transcriptome has not been evaluated.

Objective

The purpose of this study was to investigate transcriptome-wide changes that occur to tendon-derived fibroblasts following treatment with AGEs. We propose to complete a descriptive approach to pathway profiling to broaden our mechanistic understanding of cell signaling events that may contr

SUBMITTER: Patel SH 

PROVIDER: S-EPMC9321369 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature