A human model of bilateral pulmonary vein sampling to assess the effects of one-lung ventilation on neutrophil function.

ABSTRACT:

Background

Neutrophil activation drives lung complications after cardiopulmonary bypass (CPB). Evidence suggests the healthy, ventilated lung may beneficially re-condition pro-inflammatory neutrophils. However, evidence in humans is lacking, due to a paucity of good models. CPB with simultaneous central venous and bilateral pulmonary vein sampling provides an opportunity to model effects of one-lung ventilation. The study's primary objectives were to establish a model of intra-operative, bilateral pulmonary vein sampling and to determine whether neutrophil function differed after passing through inflated or deflated lungs.

Methods

Seventeen patients having "on pump" coronary artery bypass grafting (CABG) with one-lung ventilation (in two cohorts with tidal volume 2ml kg-1 an

SUBMITTER: Funston W 

PROVIDER: S-EPMC9321419 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature