Switch-associated protein 70 protects against nonalcoholic fatty liver disease through suppression of TAK1.

ABSTRACT:

Background and aims

NAFLD is a progressive disease without known effective drug treatments. Switch-associated protein 70 (SWAP70) is a guanine nucleotide exchange factor that participates in the regulation of many cellular processes. However, the role of SWAP70 in NAFLD remains unclear. This study aimed to identify the function and mechanism of SWAP70 in NAFLD.

Approach and results

The results showed that the expression of SWAP70 was significantly increased in mice and hepatocytes after metabolic stimulation. Overexpression of SWAP70 in hepatocytes suppressed lipid deposition and inflammation, and SWAP70 knockdown created the inverse effect. Using hepatocyte-specific Swap70 knockout and overexpression mice fed a high-fat, high-cholesterol diet, we demonstrated that SWAP70 su

SUBMITTER: Qian Q 

PROVIDER: S-EPMC9321549 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature