Dataset Information

Sports and trauma as risk factors for Motor Neurone Disease: New Zealand case-control study.

ABSTRACT:

Objectives

To assess whether sports, physical trauma and emotional trauma are associated with motor neurone disease (MND) in a New Zealand case-control study (2013-2016).

Methods

In total, 321 MND cases and 605 population controls were interviewed collecting information on lifetime histories of playing sports, physical trauma (head injury with concussion, spine injury) and emotional trauma (14 categories). ORs were estimated using logistic regression adjusting for age, sex, ethnicity, socioeconomic status, education, smoking status, alcohol consumption and mutually adjusting for all other exposures.

Results

Head injury with concussion ≥3 years before diagnosis was associated with MND (OR 1.51, 95% CI: 1.09-2.09), with strongest associations for two (OR 4.01, 95% CI: 1.82-8.86), and three or more (OR 2.34, 95% CI: 1.00-5.45) head injuries. Spine injury was not associated with MND (OR 0.81, 95% CI: 0.48-1.36). Compared to never playing sports, engaging in sports throughout childhood and adulthood increased MND risk (OR 1.81, 95% CI: 1.01-3.25), as was more than 12 years playing football/soccer (OR 2.35, 95% CI: 1.19-4.65). Reporting emotionally traumatic events in more than three categories was associated with MND (OR 1.88, 95% CI: 1.17-3.03), with physical childhood abuse the only specific emotional trauma associated with MND (OR 1.82, 95% CI: 1.14-2.90), particularly for those reporting longer abuse duration (OR_(5-8 years) 2.26, 95% CI: 1.14-4.49; OR_(>8 years) 3.01, 95% CI: 1.18-7.70). For females, having witnessed another person being killed, seriously injured or assaulted also increased MND risk (OR 2.68, 95% CI: 1.06-6.76).

Conclusions

This study adds to the evidence that repeated head injury with concussion, playing sports in general, and playing football (soccer) in particular, are associated with an increased risk of MND. Emotional trauma, that is physical abuse in childhood, may also play a role.

SUBMITTER: Chen GX

PROVIDER: S-EPMC9321578 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Sports and trauma as risk factors for Motor Neurone Disease: New Zealand case-control study.

Chen Grace Xia GX Douwes Jeroen J van den Berg Leonard H LH Glass Bill B McLean David D 't Mannetje Andrea Martine AM

Acta neurologica Scandinavica 20220331 6

<h4>Objectives</h4>To assess whether sports, physical trauma and emotional trauma are associated with motor neurone disease (MND) in a New Zealand case-control study (2013-2016).<h4>Methods</h4>In total, 321 MND cases and 605 population controls were interviewed collecting information on lifetime histories of playing sports, physical trauma (head injury with concussion, spine injury) and emotional trauma (14 categories). ORs were estimated using logistic regression adjusting for age, sex, ethnic ...[more]

PMID: 35355246

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Dataset Information

Sports and trauma as risk factors for Motor Neurone Disease: New Zealand case-control study.

Objectives

Methods

Results

Conclusions

Publications

Sports and trauma as risk factors for Motor Neurone Disease: New Zealand case-control study.

Similar Datasets

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