Stochastic parcel tracking in an Euler-Lagrange compartment model for fast simulation of fermentation processes.

ABSTRACT: The compartment model (CM) is a well-known approach for computationally affordable, spatially resolved hydrodynamic modeling of unit operations. Recent implementations use flow profiles based on Computational Fluid Dynamics (CFD) simulations, and several authors included microbial kinetics to simulate gradients in bioreactors. However, these studies relied on black-box kinetics that do not account for intracellular changes and cell population dynamics in response to heterogeneous environments. In this paper, we report the implementation of a Lagrangian reaction model, where the microbial phase is tracked as a set of biomass-parcels, each linked with an intracellular composition vector and a structured reaction model describing their intracellular response to extracellular variations. A sto

SUBMITTER: Haringa C 

PROVIDER: S-EPMC9321588 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature