Pareto optimal metabolic engineering for the growth-coupled overproduction of sustainable chemicals.

ABSTRACT: Our research aims to help industrial biotechnology develop a sustainable economy using green technology based on microorganisms and synthetic biology through two case studies that improve metabolic capacity in yeast models Yarrowia lipolytica (Y. lipolytica) and Saccharomyces cerevisiae (S. cerevisiae). We aim to increase the production capacity of beta-carotene (β-carotene) and succinic acid, which are among the highest market demands due to their versatile use in numerous consumer products. We performed simulations to identify in silico ranking of strains based on multiple objectives: the growth rate of yeast microorganisms, the number of used chromosomes, and the production capability of β-carotene (for Y. lipolytica) and succinate (for S. cerevisiae). Our multiobjective optimization me

SUBMITTER: Amaradio MN 

PROVIDER: S-EPMC9321710 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature