Mirtazapine exposure in pregnancy and fetal safety: A nationwide cohort study.

ABSTRACT:

Objective

To investigate the association between mirtazapine exposure in pregnancy and risk of specific adverse pregnancy outcomes.

Methods

A register-based nationwide cohort study was conducted including all registered pregnancies in Denmark from 1997 to 2016. Mirtazapine-exposed pregnancies were compared with mirtazapine unexposed pregnancies in a 1:4 ratio matched according to propensity scores. Outcomes were major congenital malformations analyzed using log binomial models, and spontaneous abortion, stillbirth and neonatal death analyzed using Cox proportional hazard regression.

Results

From a source population of 1,650,649 pregnancies, the propensity score-matched cohort included 4475 pregnancies (895 mirtazapine exposed) in the analysis of major congenital malfo

SUBMITTER: Ostenfeld A 

PROVIDER: S-EPMC9321713 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature