The relationship between sexual dimorphism and androgen response element proliferation in primate genomes.

ABSTRACT: In the males of many vertebrate species, sexual selection has led to the evolution of sexually dimorphic traits, which often are developmentally controlled by androgen signaling involving androgen response elements (AREs). Evolutionary changes in the number and genomic locations of AREs can modify patterns of receptor regulation and potentially alter gene expression. Here, we use recently sequenced primate genomes to evaluate the hypothesis that the strength of sexual selection is related to the genome-wide number of AREs in a diversifying lineage. In humans, we find a higher incidence of AREs near male-biased genes and androgen-responsive genes when compared to randomly selected genes from the genome. In a set of primates, we find that gains or losses of AREs proximal to genes are correla

SUBMITTER: Anderson AP 

PROVIDER: S-EPMC9321733 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature