Dataset Information

The role of solar and geomagnetic activity in endothelial activation and inflammation in the NAS cohort.

ABSTRACT: This study investigated the associations between solar and geomagnetic activity and circulating biomarkers of systemic inflammation and endothelial activation in the Normative Aging Study (NAS) cohort. Mixed effects models with moving day averages from day 0 to day 28 were used to study the associations between solar activity (sunspot number (SSN), interplanetary magnetic field (IMF)), geomagnetic activity (planetary K index (Kp index), and various inflammatory and endothelial markers. Biomarkers included intracellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), C-reactive protein (CRP), and fibrinogen. After adjusting for demographic and meteorological variables, we observed significant positive associations between sICAM-1 and sVCAM-1 concentrations and solar and geomagnetic activity parameters: IMF, SSN, and Kp. Additionally, a negative association was observed between fibrinogen and Kp index and a positive association was observed for CRP and SSN. These results demonstrate that solar and geomagnetic activity might be upregulating endothelial activation and inflammation.

SUBMITTER: Schiff JE

PROVIDER: S-EPMC9321765 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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The role of solar and geomagnetic activity in endothelial activation and inflammation in the NAS cohort.

Schiff Jessica E JE Vieira Carolina L Z CLZ Garshick Eric E Wang Veronica V Blomberg Annelise A Gold Diane R DR Schwartz Joel J Tracy Samantha M SM Vokonas Pantel P Koutrakis Petros P

PloS one 20220726 7

This study investigated the associations between solar and geomagnetic activity and circulating biomarkers of systemic inflammation and endothelial activation in the Normative Aging Study (NAS) cohort. Mixed effects models with moving day averages from day 0 to day 28 were used to study the associations between solar activity (sunspot number (SSN), interplanetary magnetic field (IMF)), geomagnetic activity (planetary K index (Kp index), and various inflammatory and endothelial markers. Biomarker ...[more]

PMID: 35881632

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Project description:BackgroundIncreased solar and geomagnetic activity (SGA) may alter sympathetic nervous system activity, reduce antioxidant activity, and modulate physiochemical processes that contribute to atmospheric aerosols, all which may reduce pulmonary function.ObjectivesInvestigate associations between forced expiratory volume at 1 s (FEV1) and forced vital capacity (FVC) with SGA, and assess whether SGA enhances adverse effects of particulate pollution, black carbon (BC) and particulate matter ≤2.5 μm in diameter (PM2.5).MethodsWe conducted a repeated measures analysis in 726 Normative Aging Study participants (Boston, Massachusetts, USA) between 2000 and 2017, using interplanetary magnetic field (IMF), planetary K index (Kp), and sunspot number (SSN) as SGA measures. Linear mixed effects models were used to assess exposure moving averages up to 28 days for both SGA and pollution.ResultsIncreases in IMF, Kp Index and SSN from the day of the pulmonary function test averaged through day 28 of were associated with a significant decrement in FEV1 and FVC, after adjusting for potential confounders. There were greater effects for longer moving averages and enhanced effects of PM2.5 and BC on FEV1 and FVC with increased SGA. For example, for each inter-quartile increase (4.55 μg/m3) in average PM2.5 28 days before testing, low IMF (10th percentile: 3.2 nT) was associated with a -21.4 ml (95 % CI: -60.8, 18.1) and -7.1 ml (95 % CI: -37.7, 23·4) decrease in FVC and FEV1, respectively; high IMF (90th percentile: 9.0 nT) was associated with a -120.7 ml (95 % CI:-166.5, -74.9) and -78.6 ml (95 % CI: -114.3, -42·8) decrease in FVC and FEV1, respectively.DiscussionIncreased periods of solar and geomagnetic activity may directly contribute to impaired pulmonary function and also enhance effects of PM2.5 and BC. Since exposure to solar activity is ubiquitous, stricter measures in reducing air pollution exposures are warranted, particularly in elderly populations.

Project description:BackgroundShort-term geomagnetic disturbances (GMD) driven by the quasi-periodic 11-year cycle of solar activity have been linked to a broad range of adverse health effects, including cardiovascular diseases (CVD) and total deaths. We conducted a large epidemiological study in 263 U.S. cities to assess the effects of GMD on daily deaths of total, CVD, myocardial infarction (MI), and stroke.MethodsWe employed a two-step meta-analysis approach, in which we estimated city-specific and season-stratified mortality risk associated with a GMD parameter (Kp index) in 263 U.S. cities. In addition, sensitivity analysis was performed to assess whether effect modification of particulate matter (PM2.5) in the prior day changed Kp index effects on daily deaths after adjusting for confounders.ResultsWe found significant association between daily GMD and total, CVD, and MI deaths. The effects were even stronger when we adjusted the models for 24-h PM2.5 for different seasons. For example, in the winter and fall one standard deviation of z-score Kp index increase was associated with a 0.13 and 0.31% increase in total deaths, respectively (Winter: p = 0.01, 95% CI: 0.02 to 0.24; Fall: p = 0.00001; 95% CI: 0.23 to 0.4), without adjusting for PM2.5. The effects of GMD on total deaths were also observed in spring and summer in the models without PM2.5 (p = 0.00001). When the models were adjusted for PM2.5 the total deaths increased 0.47% in winter (p = 0.00001, 95% CI: 0.3 to 0.65) and by 0.23% in fall (p = 0.001, 95% CI: 0.09 to 0.37). The effects of GMD were also significant associated with MI deaths and CVD. No positive significant association were found between Kp and stroke. The GMD effects on deaths were higher than for 24 h-PM2.5 alone, especially in spring and fall.ConclusionOur results suggest that GMD is associated with total, CVD and MI deaths in 263 U. S cities. Increased mortality in the general population during GMD should be further investigated to determine whether those human physiological dynamics driven by variations in solar activity can be related to daily clinical cardiovascular observations.

Dataset Information

The role of solar and geomagnetic activity in endothelial activation and inflammation in the NAS cohort.

Publications

The role of solar and geomagnetic activity in endothelial activation and inflammation in the NAS cohort.

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