The evolutionary path of chemosensory and flagellar macromolecular machines in Campylobacterota.

ABSTRACT: The evolution of macromolecular complex is a fundamental biological question, which is related to the origin of life and also guides our practice in synthetic biology. The chemosensory system is one of the complex structures that evolved very early in bacteria and displays enormous diversity and complexity in terms of composition and array structure in modern species. However, how the diversity and complexity of the chemosensory system evolved remains unclear. Here, using the Campylobacterota phylum with a robust "eco-evo" framework, we investigated the co-evolution of the chemosensory system and one of its important signaling outputs, flagellar machinery. Our analyses show that substantial flagellar gene alterations will lead to switch of its primary chemosensory class from one to another

SUBMITTER: Mo R 

PROVIDER: S-EPMC9321776 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature