Ontology highlight
ABSTRACT:
SUBMITTER: Santos D
PROVIDER: S-EPMC9321812 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Santos Dulce D Verdonckt Thomas-Wolf TW Mingels Lina L Van den Brande Stijn S Geens Bart B Van Nieuwerburgh Filip F Kolliopoulou Anna A Swevers Luc L Wynant Niels N Vanden Broeck Jozef J
Viruses 20220630 7
Insect antiviral immunity primarily relies on RNAi mechanisms. While a key role of small interfering (si)RNAs and AGO proteins has been well established in this regard, the situation for PIWI proteins and PIWI-interacting (pi)RNAs is not as clear. In the present study, we investigate whether PIWI proteins and viral piRNAs are involved in the immunity against single-stranded RNA viruses in lepidopteran cells, where two PIWIs are identified (Siwi and Ago3). Via loss- and gain-of-function studies i ...[more]