Volumetric differences in hippocampal subfields and associations with clinical measures in myalgic encephalomyelitis/chronic fatigue syndrome.

ABSTRACT: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients suffer from a cognitive and memory dysfunction. Because the hippocampus plays a key role in both cognition and memory, we tested for volumetric differences in the subfields of the hippocampus in ME/CFS. We estimated hippocampal subfield volumes for 25 ME/CFS patients who met Fukuda criteria only (ME/CFS_Fukuda ), 18 ME/CFS patients who met the stricter ICC criteria (ME/CFS_ICC ), and 25 healthy controls (HC). Group comparisons with HC detected extensive differences in subfield volumes in ME/CFS_ICC but not in ME/CFS_Fukuda . ME/CFS_ICC patients had significantly larger volume in the left subiculum head (p < 0.001), left presubiculum head (p = 0.0020), and left fimbria (p =

SUBMITTER: Thapaliya K 

PROVIDER: S-EPMC9321967 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature