Leveraging single-cell sequencing to unravel intratumour heterogeneity and tumour evolution in human cancers.

ABSTRACT: Intratumour heterogeneity (ITH) and tumour evolution are well-documented phenomena in human cancers. While the advent of next-generation sequencing technologies has facilitated the large-scale capture of genomic data, the field of single-cell genomics is nascent but rapidly advancing and generating many new insights into the complex molecular mechanisms of tumour biology. In this review, we provide an overview of current single-cell DNA sequencing technologies, exploring how recent methodological advancements have enumerated new insights into ITH and tumour evolution. Areas highlighted include the potential power of single-cell genome sequencing studies to explore evolutionary dynamics contributing to tumourigenesis through to progression, metastasis, and therapy resistance. We also explor

SUBMITTER: Bowes AL 

PROVIDER: S-EPMC9322001 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature