Emerging Role of Deubiquitinating Enzymes (DUBs) in Melanoma Pathogenesis.

ABSTRACT: Metastatic melanoma is the leading cause of death from skin cancer. Therapies targeting the BRAF oncogenic pathway and immunotherapies show remarkable clinical efficacy. However, these treatments are limited to subgroups of patients and relapse is common. Overall, the majority of patients require additional treatments, justifying the development of new therapeutic strategies. Non-genetic and genetic alterations are considered to be important drivers of cellular adaptation mechanisms to current therapies and disease relapse. Importantly, modification of the overall proteome in response to non-genetic and genetic events supports major cellular changes that are required for the survival, proliferation, and migration of melanoma cells. However, the mechanisms underlying these adaptive response

SUBMITTER: Ohanna M 

PROVIDER: S-EPMC9322030 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature