Reduced Endocannabinoid Tone in Saliva of Chronic Orofacial Pain Patients.

ABSTRACT:

Background

the endocannabinoid system (ECS) participates in many physiological and pathological processes including pain generation, modulation, and sensation. Its involvement in chronic orofacial pain (OFP) in general, and the reflection of its involvement in OFP in salivary endocannabinoid (eCBs) levels in particular, has not been examined.

Objectives

to evaluate the association between salivary (eCBs) levels and chronic OFP.

Methods

salivary levels of 2 eCBs, anandamide (AEA), 2-arachidonoylglycerol (2-AG), 2 endocannabinoid-like compoundsN-palmitoylethanolamine (PEA), N-oleoylethanolamine (OEA), and their endogenous precursor and breakdown product, arachidonic acid (AA), were analyzed using liquid chromatography/tandem mass spectrometry in 83 chronic

SUBMITTER: Haviv Y 

PROVIDER: S-EPMC9322033 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature