Synergistic impact of motion and acquisition/reconstruction parameters on ¹⁸ F-FDG PET radiomic features in non-small cell lung cancer: Phantom and clinical studies.

ABSTRACT:

Objectives

This study is aimed at examining the synergistic impact of motion and acquisition/reconstruction parameters on ¹⁸ F-FDG PET image radiomic features in non-small cell lung cancer (NSCLC) patients, and investigating the robustness of features performance in differentiating NSCLC histopathology subtypes.

Methods

An in-house developed thoracic phantom incorporating lesions with different sizes was used with different reconstruction settings, including various reconstruction algorithms, number of subsets and iterations, full-width at half-maximum of post-reconstruction smoothing filter and acquisition parameters, including injected activity and test-retest with and without motion simulation. To simulate motion, a special motor was manufactured to simulate re

SUBMITTER: Hosseini SA 

PROVIDER: S-EPMC9322423 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature