Previously unrecognized risk factors for severe hypoglycaemia requiring emergency medical care in insulin-treated type 2 diabetes: Results from a real-world nested case-control study.

ABSTRACT:

Aim

Several risk factors for severe hypoglycaemia (SH) are associated with insulin-treated diabetes. This study explored potential risk factors in adults with insulin-treated type 2 diabetes mellitus (T2DM).

Materials and methods

In this case-control study, adults with T2DM initiating insulin were identified in the IQVIA PharMetrics® Plus database. The index date was the date of the first SH event (cases). Using incidence-density sampling, controls were selected from those who had been exposed 'at risk' of SH for the same amount of time as each case. After exact-matching on the well-established factors, previously unreported risk factors were evaluated through conditional logistic regression.

Results

In 3153 case-control pairs, pregnancy [odds ratios (OR) = 3.20, p = 

SUBMITTER: Settles J 

PROVIDER: S-EPMC9322525 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature